Until relatively recently, canine
herpes seemed to be a problem only in the whelping boxes maintained by rank
novices in breeding dogs. Experienced breeders could control it, prevent the
effects. But it appears that perhaps a different strain of virus is running
rampant and causing more and different problems for breeders. From the website
www.canineherpes.com comes the comment “Canine herpes virus … has been largely
forgotten for many years, due in part to the difficulty in making a definitive
diagnosis. However, it is becoming increasingly clear that the virus causes many
more problems than was first thought.” They were speaking mostly of the
fading-puppy syndrome where entire litters die off, one pup at a time, in the
course of a day or two at most.
Herpes is caused by a virus. Demodectic mange is caused by the action of a
parasitic mite on the dog that has a weak immune system. Alike as night and day,
you might think, but there are one or two similarities: some dogs are more
resistant to such attacks than others, and the causative or triggering culprits
are almost everywhere. A close similarity in control and resistance is in the
response to other antigens, such as hookworm, coccidiosis, and even parvo. None
of these is an automatic death sentence if the dog is an adult or adolescent,
and is otherwise healthy. The very young and the very old are less able to fight
off new microbial or parasitic attacks. The more such stresses are put on these
individuals, the worse the prognosis. I have seen puppies die of combinations
like coccidiosis and hook, when they would have survived if only one of those
had been present. I have seen adults exposed to parvo for the first time and
come through the ordeal just fine. But combine the threats, or aim them at the
age extremes, and mortality rates become very high.
What I meant by the omnipresence of antigens is that Demodex mites, for example
can be found on perhaps well over 90% of dogs and a big percentage of humans.
(One researcher said, “This disease can literally be carried home on your
clothing.”) It’s like dust or pollen… everywhere. But with an immune system not
up to par, and a combination of stress factors, and you have dangerous, even
fatal consequences. I once bought a bitch puppy for my mother. The pup developed
severe generalized demodecosis — so bad that all attempts at control failed, and
she had to be euthanized. Oestrus is by far the most stressful trigger for
demodicosis. Herpes virus, though an entirely different organism, also exists on
or in nearly all animals, including probably a transient and harmless guest on
humans. However, we therefore could transmit the virus to our dogs. Virus
particles do not live forever in non-nutrient (host) environments, but long
enough to be carried to the ultimate host on clothing, by sneezes, etc. It is
the immune-challenged weakened pup that would fall to its onslaught. One
difference between Demodex and Herpes is that the mite is alive and active,
though ineffective against a healthy dog; herpes virus microbes enter a dormant
state and are “awakened” by various stresses. Merial says, “Most animals have
already been exposed. Although it can be spread at mating, it is much more
likely to be spread by simple contact.”
According to an Australian website, and an article by Dr. Mary Wakefield,
“Puppies die of Herpes only so long as they are unable to mount a fever
response, or have the lower body temperature of neonates. After 3 weeks of age
puppies can raise their body temperatures high enough to resist the overwhelming
infection which results in death. The treatment for Herpes in young puppies with
the appropriate signs is elevation of the body temperature. Check with your
veterinarian if you think this may be the problem in your litter under three
weeks of age.” The problem with that advice is that by the time one has a clue
to the presence of the disease (the first dead or dying puppy), it is too late.
The others are likely to have been just as chilled during a period of exposure
to the virus. And in weakened pups, the virus can replicate like wildfire.
Unfortunately, the Wakefield piece, while very helpful overall, has some minor
problems. For example, she states, “The best way of preventing newborn puppies
from acquiring the disease is to quarantine them and their dam from 3 weeks
prior to birth and 3 weeks after whelping.” If the virus is everywhere, as it
almost always is, that is no solution. There are only two ways (1.5, really)
that I have confidence in to prevent neonatal deaths from herpes: elevated
ambient temperature during the first three weeks, and the possibility of the
Merial vaccine (but still, I would not lower the thermostat!). Wakefield says,
“Herpes infection of the dam which does not result in abortion may result in low
birth weight, weak, or stillborn puppies.” And, she says that titres show herpes
activity in 80% of bitches who had lost their litters, even though there was no
bacterial blame. Wakefield advocates isolation, but I believe that’s a lost
cause; Merial states, “The virus does not come from bad kennels – it is already
everywhere!”
Since immunity is very short-lived, contracting the problem again and again is
to be expected. Dogs have fluctuating titre levels all the time, some of it due
to new exposures, some due to stress-released previously dormant particles.
In the next few paragraphs, I will quote from my book, The Total German Shepherd
Dog http://www.Hoflin.com and give you what we used to know about it. Then I
will return to some of the reports and difficulties that exist early in 2004. I
certainly hope they will be resolved by year’s end!
Herpes — There are many organisms in the virus family called herpes, the most
common in dogs being the puppy killer at ages of around two weeks or less.
Herpes seems to be present in most dogs most of the time, but some pups are more
susceptible or under more stress, which lowers their resistance. New puppies
that are not given adequate drying, heat, and nursing opportunity (internal
warming) right after delivery are most at risk. Once the disease has been
noticed in a litter, few survive. Prevention is the only remedy in nearly all
cases. It is practically unstoppable once noticed.
Neonatal deaths and Herpes viremia — This syndrome, caused by a herpes virus, is
a major cause of death in pups between five days and three weeks, and may take
two weeks to spread through the litter. “Herpes” actually refers to a class of
several viruses, so you may encounter the word used in the context of a human
disease, or a disease in other animals. One of this class will not produce the
same disease as will another. With this viremia, death from kidney and liver
failure usually occurs within eighteen hours; symptoms include constant crying,
shallow and rapid breathing, loss of appetite and coordination, and a soft,
yellowish green stool with no particular odour. The stool symptom can be easily
missed if the bitch is cleaning her pups to make them defecate.
Treatment includes elevating the environmental temperature, thus creating a sort
of artificial fever since fever is one of nature's ways of fighting virus
organisms. Close to one hundred degrees F (38 C) for the first three or more
hours post-parturition is a recommended ambient temperature, followed by 90 to
95 degrees for another 24 hours. Some people who have worries about the
drying-out effect of such high temperatures frequently give the pups glucose
solution and formula to prevent dehydration, but I have had hundreds of puppies
born to my bitches without that. I just make sure that the floor is warm or
insulated, and the heat lamp, heating pad, or low-hanging light bulb is on when
the dam is going out to “potty” for the first weeks. Herpes thrives even as high
as between 91 and 98.6 degrees F (33 to 37 degrees C), and chilled pups are
especially susceptible. At 100 or 101 degrees the virus stops replicating, so
the object is to get the pup's body temperature up to that which is considered
normal in the adult, about 102 degrees. After three weeks of age, the pup's body
temperature is usually high enough to prevent herpes growth, and by then they
have developed the shiver reflex, which is another heat-regulating mechanism.
However, because damage to kidneys may not produce symptoms until as late as ten
months of age, perhaps the surviving pups (in a litter with pups known to be
dying of hypothermia -exacerbated herpes) that show the crying symptom
associated with haemorrhage and necrosis should be euthanized right away. Ask
your veterinarian about treatment with a preparation, Vira A, designed for human
herpes encephalitis, or he may have more recent advances. But I have not seen
any good results from any kind of treatment. A few pups will survive now and
then, but regardless of treatment (other than elevated temperature).
This virus can remain latent for many months and be reactivated by stress or an
immunosuppressive agent such as a shot of cortisone or similar steroid. Thus,
pups that contract a marginal infection but not enough to be fatal, might still
have their immune system weakened, or else harbour the inactive virus. Pups seem
to get the virus through the saliva of their infected dam, though a few may
contract it in the birth canal or even in the uterus before birth. If you have a
kennel in which two or more bitches are producing litters and one loses a litter
to herpes, what should you do to save the next litter? Besides the usual step of
cleaning everything with a dilute bleach solution (as with parvo or other viral
infections), you may find success by having your veterinarian inject them with
serum obtained from the bitch that lost the litter. You may also succeed by
keeping them in the high temperature environment mentioned above.
That was the state of our knowledge in the last couple decades of the 20th
Century. We had come only so far as determining that herpes had about 90%
mortality in neonates. Now we may be on the brink of an advance in knowledge,
unfortunately brought on by an alarming increase in failures in the dog breeding
community. For some 10 or 15 years, I have been hearing more and more complaints
about bitches not conceiving. And this is a day when companies like Synbiotics
can help us zero in on the exact best time to inseminate. Progesterone, LH, and
other hormones can be tracked with simple and fast test kits, and give far
better accuracy than the vaginal cytology (study of the changing shape of cells
lining the uterus) or the physical activity of the bitch or even the most jaded
or experienced stud dog.
At least in the German Shepherd world, many of us have been blaming the fact
that so many of our bitches were “coming up empty” on the known use of anabolic
steroids given to many of the top show dogs in an attempt to boost their chances
of being placed in the very highest positions at the annual national specialty,
or even the preliminary competitions where success is considered in making
judging decisions at the final big show. There is no doubt that this goes on,
and we know that many of the top human athletes in weightlifting, football,
boxing, track, etc. are sterile or temporarily have a low sperm count.
But now, there may be another factor. Herpes appears to be the cause of many or
most of these missed matings. Nobody has been keeping statistics, so we can’t
tell how many failed breedings are costing bitch owners money and time. While a
few German clubs like the SV (for GSDs) will make note of such complaints, and
withdraw rights from males that are shooting blanks, they will not hear from
most disgruntled breeders. Stud dog owners are racking up the fees and bitch
owners are getting poorer. Correspondents in England and Australia tell me it
(failure to conceive) has been going on in their countries for some time, as it
has in the U.S. Recently, reports have come out of New Zealand and other
far-flung places. “Coming to a theatre near you!” Freight and air regulations
are prohibitive, “Homeland Security” has much adverse fallout, and even if you
can get them, delayed repeat breedings are a drain on the pocketbook. Most
Germans will not give you more than the time of day after you twist their arms
for a second breeding if the first did not take.
The increasing use of too-frequent vaccines for any and all things is another
target for blame for lack of conception and other concerns. That is, some want
to point the finger at the effect of over-vaccination on the immune and other
systems. Fewer people have other causes they want to point the finger to, but it
is a definite fact that greater numbers of people are not getting their bitches
pregnant. Perhaps the new factor in the well-known but poorly documented rise in
number of failed matings is a new herpes variety. Europe seems to have found out
that it is real. In many growing pockets on the continent, breeders are using
and reporting success with a new vaccine. In England, for example, friends tell
me of scores of bitches supposedly infertile or nearly so have been producing
very well after getting the vaccine. The word going around there is that if the
bitch is vaccinated while in oestrus or right after the bitch is mated, and
again at 6 or 7 weeks in whelp, not only is it almost always successful, but
larger litter numbers than expected seem to be the norm.
Right now, I know of only one company making the herpes vaccine, Merial. They
have said that [rough translation]: “the herpes canine virus is an infectious
and contagious disease caused by alpha herpes virus, which involves reproduction
disorders, losses of pups mainly before 3 weeks, but also of infertility,
abortions, and/or stillbirths. The vaccination which exists is used to protect
the pups less than 3 weeks at which age one finds the clinical form most
serious. The mothers receive an injection at the time of heats [oestrus] and
another injection one or two weeks before whelping. This is thus addressed
especially to the professional breeders as well as to amateurs.”
Merial also says, "Visit www.canineherpes.com for comprehensive public domain
info." and describes the virus and vaccine thusly: “EURICAN Canine herpes virus
(F205) strain antigens; Indication: Active immunisation of bitches to prevent
mortality, clinical signs and lesions in puppies resulting from canine herpes
virus infections acquired in the first few days of life.”
Merial is headquartered in Belgium, but has done much if not most of its
business in France, although national borders in Europe are getting indistinct.
French breeders I hear from tell me they are convinced the new herpes strain is
the real cause of bitches not getting pregnant as well as a reputed increase in
mummy puppies, absorbed foetuses, spontaneous abortions, stillbirths, and
neonate mortality in the first three weeks. Whether this will be substantiated
by scientific studies, I cannot forecast, but I am told that the herpes
incidence there (France) in GSDs is now about 40%, and expected to rise to 80%
in 2005. I know I have been mostly unsuccessful in getting bitches bred in the
past few years, and I hear the same complaint from many, many others around the
world.
The virus is not yet available in the U.S. Drug companies are not as aware as
they should be, or they know something they aren’t telling us. Perhaps they
don’t want to buy licensing rights to make it here, which is not likely, because
they could (and do) pass along those costs with their huge profits, to the
selling price to the vets and ultimately to you. Many people would urge every
breeder to get their brood bitches vaccinated during her oestrus period and some
say a booster before whelping. But American vaccine manufacturers are behind the
wave on this one. The suggestion that breeders have some vaccine Fed-Ex'd or
UPS'd direct from Europe to your refrigerator is nice on the surface, but the
U.S. Customs Bureau (now under control of the Homeland Security Agency) does not
allow “biological agents” to be shipped to individuals. Let's hope the U.S.
medical supply houses get on the ball right away on this, because the few
bitches that are benefiting (if indeed it works as Europe claims) are getting
their vaccines smuggled in (undeclared in the luggage of people coming from
Europe). That’s a risky way to get what you need, and would probably carry a
greater penalty than what might be placed on grey-haired seniors bussing to the
Canadian side of the river to get decent prices on their prescription drugs.
There are other causes for non-conception, of course. One person wrote me
recently about the inability to get Boston Terrier bitches pregnant, and being
just about to give up breeding. A friend suggested that she “do a sensitivity
test for bacteria near the uterus, and she did and put her dogs on an
antibiotic. (Amoxicillin wasn't doing the job.) I believe that they were put on
Baytril. Since she began treatment she now has three very pregnant bitches.” But
E. coli and other bacteria, while almost as omnipresent as Herpes and Demodex,
is relatively seldom the culprit.
Merial information tells us, “Like all herpes viruses, CHV is highly infectious,
and a recent study showed that more than 80% of the dogs tested had been exposed
to the virus at some time in their lives. Other studies have shown infection
rates of 40-100% in kennels around Europe.” They also note, “Once the virus
becomes established in kennels, periods of high mortality are interspersed with
a general fall in the average birth weight of the litter” and “the existence of
a problem only becomes apparent once a vaccination programme is put in place.”
The “epidemic” (not really an accurate term here) is going to get worse before
it gets better. Drug supply firms in the U.S. and other countries need to
determine if indeed, the conception failures are due mostly to the virus, and
that they had best get with the program and serve their customers! The AVMA and
others need to address this fatal problem rather than meddle with the long
tradition of tail docking with its two seconds of discomfort. While only a few
mentions in Merial’s promotional literature (and zero professional journal
articles so far) involve “infertility affecting several bitches”, one suggestion
under their “treatment” guidelines is simply, “Try the vaccine and see what
happens”.
To the question, “If the bitch is already pregnant, is there any point in
vaccination?”, they respond in the affirmative: “If possible, try and give two
injections, even in the last few weeks of pregnancy. Even one injection is
beneficial, though obviously the later it is given the greater the chance that
the placenta will be damaged and the unborn puppies affected.” Here again, the
emphasis is mostly on the health of puppies already conceived or whelped, not so
much on the failure to conceive. That is only brushed lightly.
My advice is to put pressure on the drug suppliers, veterinary colleges and AVMA
to get the straight facts about the effect of herpes virus on conception
failures; then, if there is confirmation of the anecdotal evidence, quickly make
a vaccine available to breeders. We have already lost enough!
